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Synchrotron-based Macromolecular Crystallography

NeoProteomics (Neo), has advanced capabilities for crystallography services. Services from crystallization trials to data collection to structural solution are available including rapid turnaround. Synchrotron-based macromolecular crystallography is one of the most important techniques to uncover the details of molecular structure at an atomic level.

NeoProteomics (Neo), in partnership with the Case Center for Synchrotron Biosciences (CSB) which has unique resources for macromolecular structure analysis at the National Synchrotron Light Source (NSLS), Brookhaven National Laboratory in New York. Two state-of-the-art beamlines operated by the CSB at the NSLS (X29 Mini-Gap Undulator and X3A Bending Magnet) are dedicated to MAD/SAD macromolecular crystallography.

The important properties of X-rays generated by synchrotrons are the high intensity and the tunability of the wavelength, which are essential for routine protein structure determination. Both CSB crystallography beamlines are easily tunable from the longer wavelengths near the iron edge (7 keV) to beyond the bromine edge (13.5 keV).