ProtMapMS

Here at Neo, we employ proprietary methods to help manage workflows. Our software, ProtMapMS^TM, analyzes data generated by highly sensitive machines, thereby significantly accelerating research and interpretation.

ProtMapMS^TM is a proprietary software tool intended to assist in the automated structural analysis of biologic-based drugs, including quality control assessment of primary structure modifications and higher-order structure analysis using covalent labeling.

For structural analyses by oxidative labeling, ProtMapMS^TM analyzes the readouts from labeled residues in the mass spectrometric analysis, providing information for mapping the protein surface and defining the solvent accessibility for residues of interest.

ProtMapMS^TM seamlessly integrates covalent labeling into workflows and provides automated functionality for:

Date Format Conversion
Mass Spectrum Interpretation
Detection & Verification of All Peptide Species
Confirmation of Peptide Modification Sites
Quantification of the Extent of Peptide Label as a Function of Covalent Label Exposure

ProtMapMS^TM:

It eliminates a major bottleneck in structural mass spectrometry experiments for biologics characterization.
It removes bias from manual calculations.
Shows a 48 person-hour time differential (in a single experiment) between expert manual methods and ProtMapMS^TM when analyzing the same data.

Input interface for ProtMapMSTM Version 2.5.0.25

Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry. Kaur P, Kiselar JG, Chance MR. Anal Chem. 2009 Oct 1;81(19):8141-9.

Typical output generated using ProtMapMS^TM. The dose-response plot is seen in the top left. The corresponding selected ion chromatograms of peptide isoforms across multiple hydroxyl radical exposure are seen on the right.

Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry. Kaur P, Kiselar JG, Chance MR. Anal Chem. 2009 Oct 1;81(19):8141-9.

NeoProteomics

Expertise. Innovation. Results.

ProtMapMS

Input interface for ProtMapMSTM Version 2.5.0.25