ProtMapMS

Here at Neo, we employ proprietary methods to help manage workflows. Our software, ProtMapMSTM, analyzes data generated by highly sensitive machines, thereby significantly accelerating research and interpretation.

ProtMapMSTM is a proprietary software tool intended to assist in the automated structural analysis of biologic-based drugs, including quality control assessment of primary structure modifications and higher-order structure analysis using covalent labeling.

For structural analyses by oxidative labeling, ProtMapMSTM analyzes the readouts from labeled residues in the mass spectrometric analysis, providing information for mapping the protein surface and defining the solvent accessibility for residues of interest.

ProtMapMSTM seamlessly integrates covalent labeling into workflows and provides automated functionality for:

  • Date Format Conversion
  • Mass Spectrum Interpretation
  • Detection & Verification of All Peptide Species
  • Confirmation of Peptide Modification Sites
  • Quantification of the Extent of Peptide Label as a Function of Covalent Label Exposure

ProtMapMSTM:

  • It eliminates a major bottleneck in structural mass spectrometry experiments for biologics characterization.
  • It removes bias from manual calculations.
  • Shows a 48 person-hour time differential (in a single experiment) between expert manual methods and ProtMapMSTM when analyzing the same data.

Input interface for ProtMapMSTM Version 2.5.0.25

Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry. Kaur P, Kiselar JG, Chance MR. Anal Chem. 2009 Oct 1;81(19):8141-9.

Typical output generated using ProtMapMSTM. The dose-response plot is seen in the top left. The corresponding selected ion chromatograms of peptide isoforms across multiple hydroxyl radical exposure are seen on the right.

Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry. Kaur P, Kiselar JG, Chance MR. Anal Chem. 2009 Oct 1;81(19):8141-9.

Contact us today with any questions you may have about ProtMapMSTM.